Sesquiterpenes and Other Constituents from the Aerial Parts of Inula japonica

Abstract

Three new sesquiterpenes, 1β-hydroxy-8β-acetoxycostic acid methyl ester, 1β-hydroxy-8β-acetoxyisocostic acid methyl ester and 1β-hydroxy-4α,11α-eudesma-5-en-12,8β-olide, along with fourteen known compounds were isolated from the aerial parts of Inula japonica. The structures of these new compounds were elucidated by spectroscopic methods (IR, EIMS, HRMS, 1D and 2D NMR). 1,6α-dihydroxy-4αH-1,10-secoeudesma-5(10),11(13)-dien-12,8β-olide exhibited appreciable cytotoxic activity against cultured SMMC-7721 (human hepatoma cell) and HO-8910 (human ovarian carcinoma cell) with IC₅₀ values of 52.22 and 21.32 μg/mL, while 5αH-eudesma-4(15),11(13)-dien-12,8β-olide showed remarkable cytotoxic activity against cultured SMMC-7721 and HO-8910 with IC₅₀ values of 6.21 and 5.28 μg/mL, respectively.

Key words

Inula japonica - Compositae - sesquiterpene - eudesmane - cytotoxic activity

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